Making Every Breath Count

Tech Brief

Continuous auscultation with the RESP has the potential to accurately diagnose COPD and asthma in both an ER/inpatient and an at-home setting, as well as in the context of clinical research. Identifying deterioration of disease or improper medication use even before patients realize their symptoms are getting worse may help to reduce costs and improve quality of care by preventing return visits to the ER and/or hospitalization. The demonstrated efficacy of the RESP makes it the gold standard for pre-diagnostic respiratory healthcare, both in the research and clinical setting, as well as in the ongoing management of chronic respiratory conditions. RESP also has potential utility in other conditions such as infectious diseases, including RSV and COVID-19. Our clinically validated bioacoustic library of sounds and RESP AI engine is the world’s largest entirely hands-free, clinical-grade dataset enabling Strados Labs to be the standard-bearer of acoustic digital biomarkers for clinical research and respiratory care globally. In the future, automation of accurate lung sound discrimination using Strados Labs proprietary AI techniques is expected to make use of continuous auscultation more timely and more cost-effective across a range of disease states.

Problem Tech Solves

Making it possible to measure lung health anytime, anywhere. Using objective respiratory data to determine treatments and therapies is needed now more than ever with staff shortages and the rise in decentralized respiratory clinical trials. RESP provides real-time access to key changes in lung acoustics and respiratory patterns. Our patent-pending algorithms pair lung sounds and breathing patterns to build a robust and accurate depiction of a patient's pulmonary sounds will allow us to leapfrog competitors in predictive analysis and detection. RESP solution has been designed to extend the range of lung sound recording both geographically and temporally to improve the standard of care when access to continuous monitoring has been replaced by less frequent monitoring. Regular auscultation and checkups are required for patients experiencing respiratory distress or disease. There are currently no effective ways for clinicians to capture abnormal patient lung sounds and patterns remotely, putting patients at risk for pulmonary decompensation between face-to-face visits. RESP is used to record patient lung sounds that can then be made available for playback, or real-time review to be monitored for changes in status. This remote, wearable stethoscope can be used for spot-checking and continuous patient wear. Strados Labs RESP fits perfectly into decentralized trials allowing remote patient access by unlocking lung sound data and putting it into the hands of the entire research team via the cloud. Making decentralized respiratory trials scalable and able to develop entirely new insights about respiratory status without episodic patient interaction leading to better trial outcomes.

Validation

ATS Abstract Study: 48 patients attending ER at NYC Health + Hospitals: Continuous auscultation versus intermittent auscultation in determining the presence of wheezes in patients presenting with asthma or COPD exacerbation *study suggests that continuous auscultation may be superior to intermittent auscultation in determining the presence of wheezes in patients presenting with asthma or COPD exacerbation. ATS Abstract Study: 40 patients with a diagnosis of COPD / asthma at the ER of New York Metropolitan Hospital: Comparison of abnormal respiratory sounds and peak expiratory flow measurements in patients presenting to the emergency room with acute exacerbation of asthma or COPD *Our data reflects that changes in count of wheezes and coughs measured with continuous auscultation are an independent assessment of treatment response in addition to PEF measurements in patients with acute asthma or COPD exacerbation. ATS Abstract Study: 5 patients with Chronic Lung Disease in Bay Area Hospital in Coos Bay, Oregon: Results of Clinical Performance Testing of a Novel Wearable e-stethoscope in Patients with Chronic Lung Diseases *In the case of lung sounds, including cough, wheeze, rhonchi, crackles, or rales the RESP® provides substantially equivalent performance to a gold standard. ATS Abstract Study: 51 patients with COVID-19, COPD, or asthma were continuously monitored during hospitalization up to 5 days: Stepwise validation program for cough detection algorithm to monitor chronic cough with Remote Electronic Stethoscope Platform (RESP®) *Strados Labs RESP® device is capable of providing accurate and sensitive cough detection in patients. Early-onset cough can be accurately detected by the RESP® device